Association of Body Mass Index with Oral Cancer Risk
최성원, 이종호, 박주영, 윤영미, 김미경,
소속 상세정보
최성원 ( Choi Sung-Weon ) - 국립암센터 구강종양클리닉
이종호 ( Lee Jong-Ho ) - 서울대학교 치과대학 구강악안면외과학교실
박주영 ( Park Joo-Young ) - 국립암센터 구강종양클리닉
윤영미 ( Yun Young-Mi ) - 국립암센터 발암원연구과
김미경 ( Kim Mi-Kyung ) - 국립암센터 발암원연구과
KMID : 0360120110330060512
Abstract
Purpose: Although obesity is a well-established risk factor for many cancers, the effect of body mass index (BMI) on oral cancer risk remains controversial. We therefore investigated the effect of BMI on oral cancer risk in a case-control study in Korea.
Methods: Overall, 364 patients with oral cancer and 439 community controls were enrolled. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression models, adjusted for age, smoking status and alcohol consumption.
Results: We found no overall significant evidence of an association between oral cancer risk and BMI in either gender. However, when the relationship between BMI and oral cancer risk was examined according to female age groups (<50 and > or =50 years), there was a significant association between oral cancer risk and high BMI in female subjects younger than 50 years of age (OR=3.92, 95% CI 1.03~14.9, P for trend=0.04), but not in older (> or =50 years) female subjects (OR=1.11, 95% CI 0.55~2.24, P for trend=0.76). There was no significant relationship between BMI and oral cancer risk in any of the male age subgroups.
Conclusion: Our study provides the first epidemiological evidence supporting an association between obesity and an increased risk of oral cancer.
키워드
Oral cancer; Obesity; Body mass index
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